Health and Disease, Uncategorized

Dad Can Pass on Ovarian Cancer Genes

 

Health and Wellness Associates

 

dadgenes

Dad Can Pass on Ovarian Cancer Genes

 

A gene mutation that’s passed down from a father is associated with earlier onset of ovarian cancer in daughters and prostate cancer in the father and his sons, a new study suggests.

 

Previous research had shown that sisters of women with ovarian cancer have a higher risk for the disease than their mother, but the reasons for this were unclear.

 

“Our study may explain why we find families with multiple affected daughters: Because a dad’s chromosomes determine the sex of his children, all of his daughters have to carry the same X chromosome genes,” said study author Kevin Eng. He’s an assistant professor of oncology at Roswell Park Comprehensive Cancer Center, in Buffalo, N.Y.

 

Eng’s team decided to look at whether genes on the X chromosome passed down from the father might influence a daughter’s risk of ovarian cancer.

 

The researchers examined data about pairs of granddaughters and grandmothers. They also sequenced portions of the X chromosome from 186 women affected by ovarian cancer.

 

The investigators discovered that women with ovarian cancer linked to genes inherited from their father’s mother developed the cancer much earlier than those with ovarian cancer linked to genes from their mother. In addition, the same genes from the father’s mother are also associated with higher rates of prostate cancer in fathers and sons.

 

Further investigation led the researchers to a previously unknown mutation on the X chromosome that may be associated with cases of ovarian cancer that develop more than six years earlier than average.

 

The findings suggest that a gene on the X chromosome may increase a woman’s risk of ovarian cancer, independent of other known risk genes, such as the BRCA genes. But the researchers did not prove that this gene causes ovarian cancer risk to rise.

 

Further research is needed to confirm the identity and function of this gene, the study authors added.

 

The study was published Feb. 15 in the journal PLoS Genetics.

 

“What we have to do next is make sure we have the right gene by sequencing more families,” Eng said in a journal news release.

 

“This finding has sparked a lot of discussion within our group about how to find these X-linked families,” Eng said. “It’s an all-or-none kind of pattern: A family with three daughters who all have ovarian cancer is more likely to be driven by inherited X mutations than by BRCA mutations.”

 

 

Health and Wellness Assocaites

Archived

Dr A Sullivan

Oncologist

312-972-WELL  (9355)

 

HealthWellnessAssocaites@gmail.com

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Health and Disease, Uncategorized

Blood Thinners – Actually Cause Strokes

Health and Wellness Associates

 

Could a Blood Thinner Actually Raise Stroke Risk for Some?

bloodthinners

Taking blood-thinning drugs is typically thought to ward off stroke in people with the heart rhythm disorder atrial fibrillation.

 

However, new research out of Britain hints — but cannot prove — that the drugs might actually raise the odds of stroke in seniors with a-fib who also have kidney disease.

 

“Chronic kidney disease is common among older people, and one in three people affected also have atrial fibrillation, commonly called an irregular heartbeat — and for that, they typically get prescribed blood thinners to reduce their risk of stroke,” noted lead researcher Shankar Kumar, of University College London (UCL).

 

However, “we found that in this particular group, their medication seems to do the opposite of its intended effect,” Kumar, a researcher with UCL’s Centre for Medical Imaging, said in a university news release.

 

Still, one U.S. cardiologist said that patients who fall into this category don’t need to panic.

 

Dr. Michael Goyman directs clinical cardiology at Northwell Health’s Long Island Jewish Forest Hills hospital, in Forest Hills, N.Y. He stressed that the new study couldn’t prove cause-and-effect and contained numerous limitations.

 

So, while the findings do need to be followed up in a more rigorous trial, “patients should not make decisions about the benefit of blood thinners without consulting their physicians,” Goyman said.

 

The new study included more than 4,800 British people, aged 65 and older, who had chronic kidney disease plus a recent diagnosis of a-fib.

 

Half of the patients were taking some sort of blood thinner for the heart condition.

 

Over an average follow-up of nearly 17 months, those taking blood thinners were 2.6 times more likely to have a stroke and 2.4 times more likely to have bleeding than those who did not take the drugs.

 

However, the death rate in the blood thinner group was slightly lower, and might have been due to a reduced risk of fatal stroke or heart attack, according to the study.

 

The findings were published Feb. 14 in the BMJ journal.

 

According to Kumar’s group, the new findings suggest doctors need to be more careful about prescribing blood thinners to seniors with chronic kidney disease, at least until more research provides a clearer idea of the risks.

 

“People with chronic kidney disease tend to have numerous severe complications, including cardiovascular illnesses,” explained senior study author John Camm, a professor of clinical cardiology at St George’s, University of London.

 

“As their blood clots more but they also bleed more easily, it is extremely difficult to strike a balance between different treatments,” he said.

 

Kumar added: “This is clearly a very complex area. We strongly call for randomized, controlled studies to test the clinical value and safety of anticoagulant drug therapy for people with both atrial fibrillation and chronic kidney disease.”

 

Dr. Satjit Bhusri is a cardiologist at Lenox Hill Hospital in New York City. He wasn’t involved in the new research but reviewed the findings and agreed that — for now at least — patients shouldn’t be concerned.

 

“This observational study is just that, observational,” and as such can’t prove that the blood thinners are somehow causing more strokes, Bhusri said. He added that important details — the types of blood thinners used, for example — weren’t included in the study.

 

In the end, Bhusri agreed with Kumar and Giyfman that more research is needed.

 

In the meantime, he said, “the choice of blood thinner should be a patient-specific preference and risk-versus-benefit should be an active discussion. I would not rely on this study as a source of reference in that discussion.”

 

Health and Wellness Assocaites

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Dr A Sullivan

Oncologist

312-972-WELL  (9355)

 

HealthWellnessAssocaites@gmail.com

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