Health and Disease, Lifestyle, Uncategorized

Lack of Sleep and Diabetes Linked

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Lack of Sleep and Diabetes Linked

 

New research links lack of sleep with heightened risk for type 2 diabetes in youth

 lackofsleep

A new review of scientific literature on the importance of sleep in youth suggests that a lack of sleep can lead to decreased appetite control and body weight regulation, all of which can raise risks for the development of type 2 diabetes.

 

The largest decline in sleep duration and poor sleep quality over the past decades has been seen in children and adolescents, a trend that earlier studies say may contribute to weight gain, increased risks for cardiovascular disease and poor mental health.

 

This new review of evidence, published in the journal Nutrition and Diabetes, has looked at 23 studies on the topic of risk factors for type 2 diabetes and sleep variables to try and elucidate the mechanisms that may explain the association between the two.

 

Researchers from Children’s Hospital of Eastern Ontario Research Institute, in Canada, reviewed studies that not only assessed risks from inadequate sleep, described as sleeping less than six hours per night – a two-hour or so sleep deficit compared to standard advice for children – but also sleep architecture.

 

A healthy sleep architecture refers to having the right number of restorative sleep cycles and rapid eye movement phases to feel sufficiently well-rested. An out of whack sleep architecture has been associated in past studies with insulin resistance.

 

In terms of sleep duration, researchers have found that the lowest risk for type 2 diabetes is observed, similar to the figure given for adults, at a minimum sleep duration of seven to eight hours per day.

 

Drawing from the findings of the different studies evaluated, they have identified a number of mechanisms by which the lack of sleep can elevate risks for type 2 diabetes among children.

 

One of them, perhaps the most prominent one, is the increased exposure to the stress hormone cortisol due to short sleep duration. This may contribute to the accumulation of visceral fat and subsequent increased insulin resistance.

 

The reason for this is that the authors also noted that the association between sleep quality and insulin resistance was not independent of the level of adiposity – the increase in the number of fat cells.

 

There may also be another phenomenon implicated that has to do with the nervous system which, in response to the stress of not sleeping, negatively influences the hormone leptin.

 

While we sleep, leptin usually rise to control appetite. However, when sleep is restricted, leptin gets inhibited. The inhibition of leptin leads to an increase in hunger and a decrease in satiety. These effects can translate into progressive weight gain.

 

Sleep is a modifiable lifestyle habit associated with the prevention of type 2 diabetes. One randomised trial that was part of the review conducted among children aged 8 to 11 years showed that increasing sleep duration by just 1.5 hour per night over a week resulted in lower food intake and lower body weight.

 

Although more studies are needed to shed light on the mechanisms linking insufficient sleep with type 2 diabetes risk, there’s no possible risk in children and teens improving their sleep and getting enough of it on a regular schedule each night.

 

If you need help, have concerns or just want a healthcare plan for YOU, then contact us and we will help you.

 

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Lifestyle, Uncategorized

Secrets of Sleep

Secrets-of-Sleep

The Secrets of Sleep

There are lots of reasons why older folks struggle to get a good night’s sleep. Just don’t expect much consensus from the scientific community.

 

Sleep is a precious commodity here in Geezerville. At a certain age, in fact, we begin to pursue it with the sort of evolutionary fervor we once reserved primarily for procreative activities. And yet, for many elderly Americans, a good night’s sleep remains a maddeningly elusive goal. As Jane Brody notes in a recent New York Times column, a 1995 study found that 28 percent of people over 65 had difficulty falling asleep and 42 percent said they had trouble falling asleep and staying asleep. Given our current propensity to while away our evening hours staring at various electronic screens, Brody suggests those numbers are probably even higher now.

 

I am not one of these cranky insomniacs. Most evenings, I’m conked out within a few minutes of my 11 o’clock bedtime; most mornings, I rise reasonably refreshed, around 8. My Lovely Wife, on the other hand, is a night owl who will not entertain the notion of slumber until she is completely convinced she’s exhausted enough — physically and, more importantly, mentally — to hit the pillow and stay there.

 

She’s been this way since our first child was born, nearly 29 years ago. Hyperalert to any disturbances from the crib down the hall, and secure in the knowledge that I’ve been known to sleep through minor earthquakes, she took on the responsibility and maintains it now, long after our offspring have exited the nest.

 

I’d worry about MLW if she wasn’t able to snooze happily into the mid-morning hours when necessary. (She’s self-employed and has few time-sensitive obligations.) But for those aging insomniacs who never catch enough z’s, there can be serious consequences: cognitive disorders, psychomotor retardation, immune system dysfunction, and depression, among others.

 

Scientists, physicians, and psychiatrists have been trying to figure out the mysteries of sleep for as long as people have been tossing and turning. There are plenty of suggested cures — avoiding caffeine, alcohol, and computer screens before bedtime; ramping up your exercise; eschewing midday naps; and the like — but there’s little consensus on what might be happening in the body to make us more or less likely to snooze. Or why we need to sleep at all.

 

Researchers at Harvard Medical School recently weighed in on the debate with a study suggesting that it’s all connected to the body’s immune response, specifically certain type of brain-based immune proteins known as inflammasome NLRP3. When the brain detects an infection or inflammation in the body, it releases sleep-inducing immune molecules.

 

“We already know that sleep plays a protective role in resolving infections so our observation of inflammasome activation following infection suggests this immune mechanism may have a brain-protective role,” says lead study author Mark Zielinski, PhD.

 

I’m no sleep expert, but this would lead me to believe that my nightly snoozefest is the happy result of some stubborn infection, which seems to be something of a mixed blessing. Eradicate the infection, douse the inflammation, and the reward is an endless string of sleepless nights?

 

No one really questions that there is a restorative function to sleep, but University of Wisconsin–Madison scientists argue that its primary purpose is to help us forget. In a recent study published in the journal Science, biologists Giulio Tononi, MD, PhD, and Chiara Cirelli, MD, PhD, report that the brain’s synapses grow so exuberantly during the day that the circuits get too noisy. When we sleep, our brains surreptitiously delete unnecessary memories so we aren’t overloaded with useless information, rendering our useful memories fuzzy.

 

When I mentioned this the other day to MLW, she wondered how the brain could determine the difference between necessary and unnecessary memories. I said I didn’t know and I wasn’t going to lose any sleep over it. But now I’m sorry I mentioned it all, because she probably will.

 

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Health and Disease, Lifestyle, Uncategorized

How You Should Sleep With Lower Back Pain?

sleepposition

How Should You Sleep with Lower Back Pain?

 

People worldwide suffer from back problems due to various reasons. In general, factors at work, excessive standing, physical exercise and even chronic medical conditions play an important role in the development lower back pain. Lower back pain interferes with your daily activities, but it also makes it difficult or even impossible to sleep at night. So how should you sleep with lower back pain?

 

Best Sleeping Position for Lower Back Pain

 

Sleep in Fetal Position

Fetal position is known to support our back and relieve any lower back pain. If you sleep on the side with the knees drawn up, your joints in the spine will open up, relieving any pressure on the structures of the back. You can also place a pillow between your legs for a better support.

 

While sleeping in this position, make sure to avoid any spine curvature. Make sure to place the pillow so that it is positioned between your knees and your ankles at the same time. Choose a thicker pillow for a better support.

 

If you sleep on the side, alternate it by sleeping on the right and on the left side as well. If you sleep on the same side all night long, you will end up with pain and even muscle imbalance.

 

For pregnant women, the best sleeping position for lower back pain is to sleep on their left side in order to avoid any pressure on the large blood structures of the body which can restrict the blood flow to the fetus.

 

Use an Extra Pillow Under the Knees

 

If you prefer sleeping on your back, you can use an extra pillow under your knees for supporting your back. This will flatten your back and avoid a large curvature of your lower back. For extra support, while sleeping on your back, you can put a rolled up towel under your lower back.

 

Don’t Sleep on Your Stomach

People suffering from lower back pain should avoid sleeping on their stomach. When sleeping on the stomach, extra pressure is put on your lower back, as well as an unpleasant twist of the spine occurs.

 

However, if this is the only position in which you can fall asleep, put a pillow under your pelvis and lower abdomen for support. If you sleep on your stomach, you don’t need a head pillow if it puts extra pressure and strain on your neck and head.

 

How to Get in and out of the Bed

 

You already know the best sleeping position for lower back pain. But have you ever thought about correct ways of getting in and out of the bed? Here is how to do it.

 

Getting into bed:

 

First, sit on the side of your bed.

Use your hands for support while you bend your knees and swing them slowly and carefully onto the bed.

Lie on your side first.

Roll onto your back using your arms for support.

 

Getting out of bed:

Once you are awake, roll on your side.

Bend your knees and let your legs hang off the bed.

Push yourself with the arms from the bed and swing your legs at the same time in order to get into a sitting position.

Stand up slowly, supporting your body with your arms.

More Tips for a Better Sleep with Lower Back Pain

 

  1. Choose the Right Mattress

 

Have you ever wondered about the best sleeping position for lower back pain? Well, not just the sleeping position, but also the mattress you sleep in is very important for a good night’s sleep. If you prefer to sleep on your side, the mattress should be soft, so your hips and shoulders sink while sleeping, avoiding any pressure to the pressure points.

 

If you prefer sleeping on your back, the mattress needs to be firm for a better comfort. The worst mattresses are those which are too soft, not offering the necessary support while sleeping.

 

  1. Buy the Right Pillows

 

The pillow you sleep in is also very important. An ideal pillow is the one that offers a neutral position where the head and the shoulders are at the same correlation. If you prefer sleeping on your side, get a thicker and firmer pillow which will help reduce the pressure on your neck.

 

If you prefer sleeping on your back, a thinner and medium firm pillow is ideal, while if you prefer sleeping on your stomach, a very thin pillow or no pillow at all is recommended.

 

  1. Relieve Your Lower Back Pain with Heat

 

Heat is known to relax the muscles of the body, including those of your lower back. For this reason, before going to bed make sure to take a shower with warm water for about 10 minutes. You can also take a hot bath if you prefer.

 

Using a heating pad or even a bottle filled with hot water can help relieve your back pain when applied to the sore area. Use the heating pad or bottle for 10 or 20 minutes, but make sure not to sleep with them. There is always the risk of burns and even fire.

 

  1. Change Your Dietary Habits

 

Eating too late or even having a large meal just before going to sleep is never recommended. It can contribute to acid reflux which will just increase your discomfort and sleeping problems. Don’t consume alcohol or caffeine in large amounts as well before going to sleep as they will disrupt your sleep too.

 

  1. Use Analgesic Rubs for Lower Back Pain

 

If you are dealing with lower back pain and are having problems sleeping, you can always try rubbing an analgesic into the sore area. This will help relax the muscles and even create a pleasant and warmth sensation.

 

  1. Don’t Sleep Too Much

Sleeping too much is not recommended as well. Adults should get about 7 to 8 hours of sleep every night. Staying for a prolonged period of time in bed will just contribute to muscle stiffness and even increase the back pain.

 

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1 in 6 Women take this Nightmare Pill

pill

1 in 6 Women Take This Nightmare Pill While Many Studies Suggest It’s Useless

 

Use of Antidepressants Continue to Rise

 

Major depression is one of the most common disorders in the U.S.,1 with 16 million adults reporting at least one major depressive episode in the past year.2,3 When you look at all forms of depression, that number goes even higher. According to the U.S. Centers for Disease Control and Prevention, nearly 24 million Americans experience some form of depression,4 which can interfere with personal and work relationships, reduce work or academic performance and affect physical health.

 

Depression reduces your ability to care for yourself properly and make adequate decisions about your health, including nutrition and sleep. Imbalances in nutrition, weight fluctuations and poor sleep habits may lead to compromised immune function.5

 

If ignored, depression can become chronic and can lead to self-harming behaviors such as drug or alcohol abuse6 and even be terminal if the person commits suicide. Up to 70 percent of people who commit suicide are clinically depressed,7 and 90 percent of people who struggle with suicidal thoughts experience a combination of depression and substance abuse.8

 

Antidepressant Use Continues to Rise

According to the latest statistics,9,10,11,12 use of antidepressants in the U.S. rose by 65 percent between 1999 and 2014. As of 2014:

 

  • Nearly 1 in 8 Americans (13 percent) over the age of 12 reported being on antidepressant medication

 

  • 1 in 6 women (16.5 percent) reported antidepressant use compared to 1 in 11 men (9 percent)

 

  • About one-quarter of those who had taken an antidepressant in the past month reported being on them for 10 years or more

 

  • Caucasians were more than three times more likely to use antidepressants than Blacks, Hispanics or Asians (16.5 percent compared to 5.6 percent, 5 percent and 3.3 percent respectively)

 

In Scotland, researchers also warn that antidepressant use among children under the age of 12 has risen dramatically.13 Between 2009 and 2016, use in this age group quadrupled. Use among children under 18 doubled in the same time frame.

 

Research Reveals Antidepressants Are Rarely the Right Answer

Unfortunately, the most widely used remedy for depression is also among the least effective. In addition to a long list of potential side effects14,15 (which include worsening depression and suicide), 40 percent of people with major depressive disorder treated with antidepressants do not achieve full remission.16

 

Perhaps more importantly, studies17,18,19 have repeatedly shown antidepressants work no better than placebo for mild to moderate depression, so you’re taking grave risks for a very small chance of benefit. As noted in a 2014 paper on antidepressants and the placebo effect:20

 

“Antidepressants are supposed to work by fixing a chemical imbalance, specifically, a lack of serotonin in the brain … But analyses of the published data and the unpublished data that were hidden by drug companies reveals that most (if not all) of the benefits are due to the placebo effect …

 

Analyzing the data we had found, we were not surprised to find a substantial placebo effect on depression. What surprised us was how small the drug effect was. Seventy-five percent of the improvement in the drug group also occurred when people were give dummy pills with no active ingredient in them.

 

The serotonin theory is as close as any theory in the history of science to having been proved wrong. Instead of curing depression, popular antidepressants may induce a biological vulnerability making people more likely to become depressed in the future.”

 

Placebo Effect Accounts for 82 Percent of Drug Response

The author of that 2014 study, Irving Kirsch, is a psychotherapist who has performed a number of analyses on antidepressants. In 2002, his team filed a Freedom of Information Act request to the U.S. Food and Drug Administration (FDA), asking for the trial data provided by drug companies as part of the drug approval process.

 

The FDA requires drug companies to provide data on all clinical trials they’ve sponsored, including unpublished trials. As it turned out, nearly half of all clinical trials on antidepressants remained unpublished. When both published and unpublished trials were included, 57 percent showed the drug had no clinical benefit over placebo. What’s more, the placebo response actually accounted for 82 PERCENT of the beneficial response to antidepressants!

 

These results were reproduced in a 2008 study21 using another, even larger set of FDA trial data. According to Kirsch, “Once again, 82 percent of the drug response was duplicated by placebo.” A major benefit of evaluating FDA trial data was that all of the trials used the same primary measure of depression, which made the drug-to-placebo effects very easy to identify and compare.

 

The primary measure of depression used in these studies was the Hamilton depression scale, a 17-item scale with a possible score of 0 to 53 points. The higher your score, the more severe your depression. Importantly, the mean difference between antidepressants and placebo was less than two points (1.8) on this scale, which is considered clinically insignificant.

 

To illustrate just how insignificant of a difference this is, you can score a 6-point difference simply by changing sleep patterns without any reported change in other depressive symptoms.

 

EMFs — A Not Well-Known Cause of Anxiety and Depression

About one year ago Dr. Martin Pall published a review22 in the Journal of Neuroanatomy showing how microwave radiation from cell phones, Wi-Fi routers and computers and tablets not in airplane mode is clearly associated with many neuropsychiatric disorders. I recently did an interview with him that will air on September 3. In the meantime, you can view my interview on EMFs that I discussed on my recent trip to visit with Dave Asprey, founder and CEO of Bulletproof.23

 

These microwave EMFs increase intracellular calcium through voltage gated calcium channels (VGCCs) and the tissue with the highest density of VGCCs is the brain. Once these VGCCs are stimulated they also cause the release of neurotransmitters and neuroendocrine hormones leading to not only anxiety and depression, but neurodegenerative diseases like Alzheimer’s and brain cancer.

 

So, if you struggle with anxiety or depression, be sure to limit your exposure to wireless technology. Simple measures include turning your Wi-Fi off at night, not carrying your cellphone on your body and not keeping portable phones, cellphones and other electric devices in your bedroom.

 

Studies have also confirmed the therapeutic effects of spending time in nature.  Ecotherapy has been shown to lower stress, improve mood and significantly reduce symptoms of depression.24 Outdoor activities could be just about anything, from walking a nature trail to gardening, or simply taking your exercise outdoors.

 

Breath work such as the Buteyko breathing technique also has enormous psychological benefits and can quickly reduce anxiety by increasing the partial pressure of carbon dioxide in your body. These three techniques are a perfect complement to each other, and cost nothing. Simply turn off your electronics, head outside and practice proper breathing.

 

America Struggles With Notable Decline in Mental Health 

While prescriptions for psychiatric drugs keep increasing (when you include other drugs beside antidepressants, such as anti-anxiety drugs, nearly 17 percent of American adults are medicated25,26), several parameters show mental health in the U.S. is declining.

 

Suicide rates are at a 30-year high, mental disorders are now the second most common cause of disability, having risen sharply since 1980,27 and prescription drug abuse and overdose deaths have become a public health emergency. While opioid pain killers are among the most lethal, psychiatric drugs also take their toll. In 2013, anti-anxiety benzodiazepine drugs accounted for nearly one-third of prescription overdose deaths.28

 

All of these statistics suggest that far from being helpful, antidepressants and other psychiatric drugs are making the situation worse. Sure, these drugs may be helpful for a small minority of people with very severe mental health problems, such as schizophrenia, but clearly, the vast majority of people using these drugs do not suffer from severe psychiatric illness.

 

Most are struggling with sadness, grief, anxiety, “the blues” and depression, which are in many ways part of your body’s communication system, revealing nutritional or sunlight deficiencies and/or spiritual disconnect, for example. The underlying reasons for these kinds of troubles are manifold, but you can be sure that, whatever the cause, an antidepressant will not correct it.

 

Women also need to be mindful of the fact that use of antidepressants during pregnancy can significantly increase your chances of having a child with autism. One study found antidepressant use during the second or third trimester was associated with an 87 percent increased risk of autism.29 The use of selective serotonin reuptake inhibitors was associated with double the risk of autism in the child, while the use of two or more antidepressants increased the risk more than fourfold.

 

Which Treatments Actually Work?

If you’re at all interested in following science-based recommendations, you’d place antidepressants at the very bottom of your list of treatment candidates. Far more effective treatments for depression include:

 

  • Exercise — A number of studies have shown exercise outperforms drug treatment. Exercise helps create new GABA-producing neurons that help induce a natural state of calm, and boosts serotonin, dopamine and norepinephrine, which helps buffer the effects of stress.

 

Studies have shown there is a strong correlation between improved mood and aerobic capacity, but even gentle forms of exercise can be effective. Yoga, for example, has received particular attention in a number of studies. A study published this spring found 90-minute yoga sessions three times a week reduced symptoms of major depression by at least 50 percent.30

 

  • Nutritional intervention — Keeping inflammation in check is an important part of any effective treatment plan. If you’re gluten sensitive, you will need to remove all gluten from your diet. A food sensitivity test can help ascertain this. Reducing lectins may also be a good idea. As a general guideline, eating a whole food diet as described in my optimal nutrition plan can go a long way toward lowering your inflammation level. Certain nutritional deficiencies are also notorious contributors to depression, especially:

 

◦ Omega-3 fats. I recommend getting an omega-3 index test to make sure you’re getting enough. Ideally, you want your omega-3 index to be 8 percent or higher.

 

◦ B vitamins (including B1, B2, B3, B6, B8 and B12). Low dietary folate can raise your risk by as much as 300 percent.31,32 One of the most recent studies33,34 showing the importance of vitamin deficiencies in depression involved suicidal teens. Most turned out to be deficient in cerebral folate and all of them showed improvement after treatment with folinic acid.

 

  • Vitamin D — Studies have shown vitamin D deficiency can predispose you to depression and that depression can respond favorably to optimizing your vitamin D stores, ideally by getting sensible sun exposure.35,36 In one such study,37 people with a vitamin D level below 20 nanograms per milliliter (ng/mL) had an 85 percent increased risk of depression compared to those with a level greater than 30 ng/mL.

 

A double-blind randomized trial38 published in 2008 concluded that supplementing with high doses of vitamin D “seems to ameliorate [depression] symptoms indicating a possible causal relationship. “Recent research39 also claims that low vitamin D levels appear to be associated with suicide attempts. For optimal health, make sure your vitamin D level is between 40 and 60 ng/mL year-round. Ideally, get a vitamin D test at least twice a year to monitor your level.

 

  • Probiotics — Keeping your gut microbiome healthy also has a significant effect on your moods, emotions and brain. You can read more in my previous article, “Mental Health May Depend on the Health of Your Gut Flora.”

 

  • Emotional Freedom Techniques (EFT) — EFT is a form of psychological acupressure that has been shown to be quite effective for depression and anxiety.40,41,42,43 For serious or complex issues, seek out a qualified health care professional that is trained in EFT44 to guide you through the process. That said, for most of you with depression symptoms, this is a technique you can learn to do effectively on your own.

 

One of my new favorites.  My mom passed away unexpectedly in July and I am very grateful she did not have cancer or struggles with any abuses from the conventional health system that many of our readers do. However, losing my mother was a major challenge in grief management for me.

 

I realize grief is not depression but the book “Letting Go: The Pathway of Surrender”45 by Dr. David Hawkins, was one of the best books I have read this year and helped teach me the useful tool of how to free yourself of painful emotions. I have read many of Hawkins’ previous books but this was his last one as he also recently passed.

 

Other Helpful Treatment Strategies

Here are several other strategies that can help improve your mental health:46

 

Clean up your sleep hygiene

 

Make sure you’re getting enough high-quality sleep, as sleep is essential for optimal mood and mental health. A fitness tracker that tracks your sleep can be a useful tool. The inability to fall asleep and stay asleep can be due to elevated cortisol levels, so if you have trouble sleeping, you may want to get your saliva cortisol level tested with an Adrenal Stress Index test.

 

If you’re already taking hormones, you can try applying a small dab of progesterone cream on your neck or face when you awaken during the night and can’t call back to sleep. Another alternative is to take adaptogens, herbal products that help lower cortisol and adjust your body to stress. There are also other excellent herbs and amino acids that help you to fall asleep and stay asleep. Meditation can also help.

Optimize your gut health

 

A number of studies have confirmed gastrointestinal inflammation can play a critical role in the development of depression.47 Optimizing your gut microbiome will also help regulate a number of neurotransmitters and mood-related hormones, including GABA and corticosterone, resulting in reduced anxiety and depression-related behavior.48

 

To nourish your gut microbiome, be sure to eat plenty of fresh vegetables and traditionally fermented foods. Healthy choices include fermented vegetables, lassi, kefir and natto. If you do not eat fermented foods on a regular basis, taking a high-quality probiotic supplement is recommended.

 

Also remember to severely limit sugars, especially fructose, as well as grains, to rebalance your gut flora. As a standard recommendation, I suggest limiting your daily fructose consumption from all sources to 25 grams per day or less.

Visualization

 

Visualization and guided imagery have been used for decades by elite athletes prior to an event, successful business people and cancer patients — all to achieve better results through convincing your mind you have already achieved successful results.49,50 Similar success has been found in people with depression.51

Cognitive Behavioral Therapy (CBT)

 

CBT has been used successfully to treat depression.52,53 This therapy assumes mood is related to the pattern of thought. CBT attempts to change mood and reverse depression by directing your thought patterns.

Make sure your cholesterol levels aren’t too low for optimal mental health

 

You may also want to check your cholesterol to make sure it’s not too low. Low cholesterol is linked to dramatically increased rates of suicide, as well as aggression toward others.54 This increased expression of violence toward self and others may be due to the fact that low membrane cholesterol decreases the number of serotonin receptors in the brain, which are approximately 30 percent cholesterol by weight.

 

Lower serum cholesterol concentrations therefore may contribute to decreasing brain serotonin, which not only contributes to suicidal-associated depression, but prevents the suppression of aggressive behavior and violence toward self and others.

Helpful supplements

 

A number of herbs and supplements can be used in lieu of drugs to reduce symptoms of anxiety and depression. These include:

 

  • St. John’s Wort (Hypericum perforatum). This medicinal plant has a long historical use for depression, and is thought to work similarly to antidepressants, raising brain chemicals associated with mood such as serotonin, dopamine and noradrenaline.55

 

  • S-Adenosylmethionine (SAMe). SAMe is an amino acid derivative that occurs naturally in all cells. It plays a role in many biological reactions by transferring its methyl group to DNA, proteins, phospholipids and biogenic amines. Several scientific studies indicate that SAMe may be useful in the treatment of depression.

 

  • 5-Hydroxytryptophan (5-HTP). 5-HTP is another natural alternative to traditional antidepressants. When your body sets about manufacturing serotonin, it first makes 5-HTP. Taking 5-HTP as a supplement may raise serotonin levels. Evidence suggests 5-HTP outperforms a placebo when it comes to alleviating depression,56 which is more than can be said about antidepressants.

 

  • XingPiJieYu. This Chinese herb, available from doctors of traditional Chinese medicine (TCM), has been found to reduce the effects of “chronic and unpredictable stress,” thereby lowering your risk of depression.57

Guidelines for Safe Drug Withdrawal

If you’re currently on an antidepressant and want to get off it, ideally, you’ll want to have the cooperation of your prescribing physician. It would also be wise to do some homework on how to best proceed. Dr. Joseph Glenmullen from Harvard has written a helpful book on how to withdraw called “The Antidepressant Solution: A Step-by-Step Guide to Overcoming Antidepressant Withdrawal, Dependence, and Addiction.”

 

You can also turn to an organization with a referral list of doctors who practice more biologically or naturally, such as the American College for Advancement in Medicine at http://www.ACAM.org. A holistic psychiatrist will have a number of treatment options in their tool box that conventional doctors do not, and will typically be familiar with nutritional supplementation.

 

Once you have the cooperation of your prescribing physician, start lowering the dosage of the medication you’re taking. There are protocols for gradually reducing the dose that your doctor should be well aware of. At the same time, it may be wise to add in a multivitamin and/or other nutritional supplements or herbs. Again, your best bet would be to work with a holistic psychiatrist who is well-versed in the use of nutritional support.

 

If you have a friend or family member who struggles with depression, perhaps one of the most helpful things you can do is to help guide them toward healthier eating and lifestyle habits, as making changes can be particularly difficult when you’re feeling blue — or worse, suicidal. Encourage them to unplug and meet you outside for walks. We should not underestimate the power of human connection, and the power of connection with nature. Both, I believe, are essential for mental health and emotional stability.

 

If you are feeling desperate or have any thoughts of suicide, please call the National Suicide Prevention Lifeline, a toll-free number: 1-800-273-TALK (8255), or call 911, or simply go to your nearest hospital emergency department. You cannot make long-term plans for lifestyle changes when you are in the middle of a crisis.

 

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Caffeine Could Help Stop Post op Pain

caffeinecould

Caffeine Could Help Stop Post-Op Pain: Study

 

New American research has found that for patients who suffer from sleep deprivation before surgery, caffeine before the operation could be an alternative way to reduce post-operative pain associated with a lack of sleep.

 

Previous research has shown that a lack of sleep both pre- and post-op can worsen pain after surgery. This new study from the Department of Anesthesiology at Michigan Medicine set out to see if there were any interventions that could help minimize the effect of sleep loss and reduce the severity of pain experienced after surgery.

 

The team focused on caffeine as a potential treatment, which may seem surprising given that caffeine is a stimulant to increase alertness.

 

“Most people would be confused by the idea of using caffeine while we insist on the dangers of not getting enough sleep,” noted study author Giancarlo Vanini, M.D.

 

However, as caffeine blocks the actions of the sleep-inducing neurotransmitter adenosine, causing us to feel more awake, the team proposed that caffeine might counteract the negative impact of sleep deprivation on surgical pain.

 

 

“Insufficient sleep enhances pain perception, so we reasoned that caffeine might also be useful for reversing the increase in pain caused by sleep loss,” Vanini said.

 

The team used a rat model of surgical pain to test whether sleep deprivation before surgery would increase postoperative pain, and whether being given caffeine pre-emptively, before the sleep deprivation, would block the increase in postoperative pain caused by this lack of sleep.

 

The results showed that sleep deprivation before surgery did indeed increase postoperative pain, and also extended recovery time after surgery.

 

However, as the team hypothesized, caffeine helped mitigate the negative effects of insufficient sleep prior to surgery, blocking the increase in surgical pain.

 

Vanini explained that caffeine’s positive effect may be due to its role in blocking neurochemical changes caused by sleep deprivation in the brain areas that control sleep and wakefulness, and are connected to major pain-related areas.

 

“These results are relevant because sleep disorders and insufficient sleep are highly prevalent problems in our society,” he added. “Additionally, often times patients travel long distances during the night or early morning before being admitted into the hospital for elective surgery. In one way or another, most patients do not get adequate sleep before surgery.”

 

The team now plan to carry out more research to better understand caffeine’s effect on reducing pain in surgical patients.

 

The results are online in the journal Sleep.

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Health and Disease, Uncategorized

Sleep Apnea Linked to Cognitive Decline

sleepapnea

Sleep Apnea Tied to Cognitive Decline

People who experience certain breathing problems at night may be more likely to develop cognitive impairment than individuals without any difficulties breathing while they sleep, a research review suggests.

Data obtained from 14 previously published studies with a total of more than 4.2 million men and women showed that people with sleep-disordered breathing had 26 percent higher odds of developing cognitive impairment, researchers report in JAMA Neurology.

“Identification of this sleep disorder in elderly persons might help predict future risk of cognitive impairment and thus is important for the early detection of dementia,” said lead study author Yue Leng of the University of California, San Francisco.

“Moreover, sleep-disordered breathing is a treatable disease,” Leng said by email. “If sleep-disordered breathing is a risk factor for dementia, then treatment of sleep-disordered breathing might benefit cognition and help reduce the risk of dementia in the long run.”

 

Many people with nighttime breathing problems had what’s known as apnea, a potentially serious sleep disorder that involves repeated stops and starts in breathing. Risk factors for sleep apnea include older age and obesity.

 

In the smaller studies included in the analysis, the increased risk of cognitive impairment associated with sleep-disordered breathing ranged from 23 percent to 86 percent.

 

When researchers analyzed the increased risk across all of the smaller studies with a similar design, excluding one that was done much differently, the overall increased risk of cognitive impairment associated with sleep-disordered breathing was 35 percent.

Sleep-disordered breathing was also associated with slightly worse “executive function” – that is, the mental processes involved in planning, paying attention, following instructions, and multi-tasking, for example – but it didn’t appear to influence memory, the study also found.

 

The researchers had only limited data on executive function, however, which made it difficult to determine whether any changes associated with sleep-disordered breathing might be clinically meaningful.

 

The analysis also didn’t account for obesity, which is independently a risk factor for both apnea and cognitive impairment, noted Marie-Pierre St-Onge, a researcher at Columbia University Medical Center in New York City who wasn’t involved in the study.

 

“It’s possible that the reduction in oxygen reaching the brain from apnea could, over time, lead to brain injuries that can lead to cognitive impairment,” St-Onge said by email. “There is also a link between obesity and mild cognitive impairment and between obesity and sleep-disordered breathing.”

 

Shedding excess weight might help, said Hui-Xin Wang of the Karolinska Institute in Stockholm.

 

“Weight-loss strategies, including physical exercise and diet, have been evaluated as a treatment strategy to improve sleep-disordered breathing and reduce the risk of cognitive decline,” Wang, who wasn’t involved in the study, said by email.

 

Beyond weight loss, treatments for apnea may include wearing a breathing mask or jaw support at night to keep airways open.

 

More research is needed, however, to determine whether and to what extent treating sleep apnea might lower the risk of cognitive decline, said Kristen Knutson of the Center for Circadian and Sleep Medicine at the Northwestern University Feinberg School of Medicine in Chicago.

 

“There are therapies available for apnea that would improve sleep and potentially improve health, including cognitive function,” Knutson, who wasn’t involved in the study, said by email. “People who have trouble sleeping or who snore loudly and frequently should raise this issue with their doctors and discuss potential treatments.”

Call us with any of your healthcare concerns.

Health and Wellness Associates

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Dr G Carney

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Health and Disease, Lifestyle, Uncategorized

Are Sleeping Problems a Warning for Alzheimer’s?

sleepingproblems

Are Sleeping Problems a Warning for Alzheimer’s?

 

Trouble getting enough sleep may be linked to a bigger risk of Alzheimer’s disease for some people, new research suggests.

 

The results of the small study hint that people with a higher-than-normal risk of Alzheimer’s disease who had worse sleep quality, more sleep problems and daytime sleepiness had more markers for Alzheimer’s disease in their spinal fluid than those who didn’t have sleep issues.

 

The markers found by researchers included signs of the proteins amyloid and tau, and brain cell damage and inflammation, all linked to potential Alzheimer’s.

 

Amyloid is a protein that folds and forms plaques. Tau is a protein that forms tangles. Plaques and tangles are found in the brains of those with Alzheimer’s disease and are considered a hallmark of the disease.

 

“This study and others in the field suggest that sleep may be a modifiable risk factor for Alzheimer’s disease,” said senior researcher Barbara Bendlin. She’s an associate professor of medicine at the University of Wisconsin School of Medicine and Public Health.

 

“This will require studies that directly test whether modifying sleep has a beneficial effect on the brain,” Bendlin said.

 

So, if you’re someone who’s always tossing and turning at night, does that mean you’re destined to a future with Alzheimer’s disease?

 

Not necessarily. Bendlin said these findings cannot prove that poor sleep causes Alzheimer’s disease. “We found an association,” she said. “But that does not mean cause and effect.”

 

It’s possible changes in the brain associated with Alzheimer’s could affect sleep, as opposed to the other way around, Bendlin added.

 

People with markers — signs — of Alzheimer’s in their spinal fluid aren’t necessarily predestined to develop the condition either, she said.

 

“We found relationships between sleep and levels of proteins related to Alzheimer’s disease, but the proteins that we were measuring haven’t yet been shown to predict future dementia when measured in cognitively healthy people,” Bendlin said.

 

 

The study included 101 people and their average age was 63. At the time of testing, all of the study volunteers had normal thinking and memory skills. But they were considered at risk for Alzheimer’s either because they had a parent with the disease or they carried a gene that increases the risk for Alzheimer’s called apolipoprotein E, or APOE.

 

The study volunteers gave a sample of spinal fluid to be tested for markers of Alzheimer’s disease.

 

They also answered questions to judge the quality of their sleep. Examples included: “During the past four weeks, how often did you get the amount of sleep you needed?” Or “Did you get enough sleep to feel rested upon waking in the morning?” Bendlin said.

 

Although a strong association between sleep problems and Alzheimer’s markers was seen in most people, not everyone with sleep difficulty had these markers in their spinal fluid, Bendlin said.

 

For example, there was no association seen between people who had sleep apnea and markers for Alzheimer’s in their spinal fluid.

 

Other factors — such as the use of drugs to aid sleep, education, depression and weight — didn’t change the association between poor sleep and markers for Alzheimer’s disease, the researchers found.

 

One thing that could have thrown the findings off is that the participants reported their own sleep problems. It’s possible that people misreported their sleep issues or didn’t remember them correctly, the researchers said.

 

One specialist said that the association between sleep and amyloid has been seen in mice, but its effect on people isn’t clear.

 

“There is a positive feedback loop involving sleep and amyloid,” said Dr. Sam Gandy, director of the Center for Cognitive Health at Mount Sinai Hospital in New York City.

 

In mice, the worse the sleep, the more amyloid builds up. The more amyloid builds up, the worse the sleep, he said.

 

It’s not known if this occurs in the same way in humans, Gandy said.

 

“Since our ability to slow progression of Alzheimer’s is still quite limited, this is an important area for research so that we might be able to exploit sleep regulation therapeutically,” he said.

 

Bendlin said it’s important to identify modifiable risk factors for Alzheimer’s because delaying Alzheimer’s disease in people by as little as five years could reduce the number of cases in the next 30 years by nearly 6 million and save $367 billion in health care costs.

 

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Health and Disease, Lifestyle, Uncategorized

Lack of Sleep and Diabetes Link

sleepingchild

Lack of Sleep and Diabetes Linked

 

New research links lack of sleep with heightened risk for type 2 diabetes in youth

 

A new review of scientific literature on the importance of sleep in youth suggests that a lack of sleep can lead to decreased appetite control and body weight regulation, all of which can raise risks for the development of type 2 diabetes.

 

The largest decline in sleep duration and poor sleep quality over the past decades has been seen in children and adolescents, a trend that earlier studies say may contribute to weight gain, increased risks for cardiovascular disease and poor mental health.

 

This new review of evidence, published in the journal Nutrition and Diabetes, has looked at 23 studies on the topic of risk factors for type 2 diabetes and sleep variables to try and elucidate the mechanisms that may explain the association between the two.

 

Researchers from Children’s Hospital of Eastern Ontario Research Institute, in Canada, reviewed studies that not only assessed risks from inadequate sleep, described as sleeping less than six hours per night – a two-hour or so sleep deficit compared to standard advice for children – but also sleep architecture.

 

A healthy sleep architecture refers to having the right number of restorative sleep cycles and rapid eye movement phases to feel sufficiently well-rested. An out of whack sleep architecture has been associated in past studies with insulin resistance.

 

In terms of sleep duration, researchers have found that the lowest risk for type 2 diabetes is observed, similar to the figure given for adults, at a minimum sleep duration of seven to eight hours per day.

 

Drawing from the findings of the different studies evaluated, they have identified a number of mechanisms by which the lack of sleep can elevate risks for type 2 diabetes among children.

 

One of them, perhaps the most prominent one, is the increased exposure to the stress hormone cortisol due to short sleep duration. This may contribute to the accumulation of visceral fat and subsequent increased insulin resistance.

 

The reason for this is that the authors also noted that the association between sleep quality and insulin resistance was not independent of the level of adiposity – the increase in the number of fat cells.

 

There may also be another phenomenon implicated that has to do with the nervous system which, in response to the stress of not sleeping, negatively influences the hormone leptin.

 

While we sleep, leptin usually rise to control appetite. However, when sleep is restricted, leptin gets inhibited. The inhibition of leptin leads to an increase in hunger and a decrease in satiety. These effects can translate into progressive weight gain.

 

Sleep is a modifiable lifestyle habit associated with the prevention of type 2 diabetes. One randomised trial that was part of the review conducted among children aged 8 to 11 years showed that increasing sleep duration by just 1.5 hour per night over a week resulted in lower food intake and lower body weight.

 

Although more studies are needed to shed light on the mechanisms linking insufficient sleep with type 2 diabetes risk, there’s no possible risk in children and teens improving their sleep and getting enough of it on a regular schedule each night.

 

If you need help, have concerns or just want a healthcare plan for YOU, then contact us and we will help you.

 

Health and Wellness Associates

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Rx to Wellness, Uncategorized

Sleep and Psychiatric Disorders

sleep

 

Sleep and psychiatric disorders often occur at the same time, and untreated sleep disorders can increase the risk of developing psychiatric conditions, such as depression, later in life. Recent reports found that as many as two-thirds of patients referred to sleep disorders centers have a psychiatric disorder. The most common psychiatric disorders associated with sleep complaints include depression, anxiety, and substance (illicit drugs and alcohol) abuse. Treating sleep disorders has been shown to improve the co-existing psychiatric condition and overall quality of life.

 

Depression

 

Depression is a mood disorder identified by low mood and/or lack of interest in activities previously found to be enjoyable. Depression affects one’s appetite, concentration, energy level, and motivation. People with depression report feelings of helplessness, hopelessness, worthlessness, and have suicidal thoughts. The majority experience symptoms of insomnia, consisting of difficulty in falling asleep, staying asleep, early morning awakening, or non-refreshing sleep.

 

Studies of depressed patients demonstrate prolonged sleep latency (time to fall asleep), lack of slow wave sleep (also known as deep sleep), reduced REM sleep latency (time to REM sleep from sleep onset), and increased amount of REM sleep. REM stands for rapid eye movement, a sleep cycle characterized by the following physiological changes:

 

Accelerated respiration

Increased brain activity

Eye movement

Muscle relaxation

There is much evidence linking depression with sleep disorders. It has been shown that insomnia increases the risk of depression and that depression can cause insomnia. In a 34-year follow-up study of medical students at Johns Hopkins Medical Center, the risk of developing depression among students with insomnia was twice that of those without insomnia. Of all the symptoms of depression, insomnia is often the last to respond to medications. Failure to treat insomnia increases the risk of a depression relapse.

 

Rarely, people with depression report excessive daytime sleepiness. This is more common in patients with seasonal affective disorder, also known as “winter depression.”

 

Anxiety disorders

 

People with anxiety disorders feel nervous, tense, have difficulty controlling worrying, and find it hard to relax. Sleep disorders are found in over 50 percent of patients with generalized anxiety disorder. Difficulty in falling and staying asleep is the most common sleep disturbance. People with anxiety disorders report a high level of psychological distress and are unable to relax enough to sleep at night. Insomnia in turn can raise anxiety levels. Nocturnal panic attacks are also common; these are sudden awakenings from sleep accompanied by intense anxiety, shortness of breath, heart palpitations, and usually lead to difficulty falling back asleep.

 

Sleep and substance abuse

 

People who abuse alcohol and other illicit drugs frequently experience sleep problems. Many people say they use alcohol and illicit drugs in order to fall asleep. However, these substances are not effective in the long run and can lead to a variety of serious health and performance problems, including psychiatric and medical disorders, and psychosocial problems such as impaired performance at school or work. Though many believe in its sleep-promoting benefits, alcohol actually disrupts sleep, causing recurrent awakenings and a reduced amount of REM sleep. The use of alcohol and other illicit drugs to treat insomnia is strongly discouraged.

 

Treatment

 

Treatment of co-existing psychiatric and sleep disorders requires a thorough evaluation by experts with knowledge in both sleep medicine and psychiatry. Medications to treat depression and anxiety must be chosen carefully, as some promote wakefulness while others cause drowsiness.

 

Cognitive Behavioral Therapy (CBT) is a structured and focused treatment for insomnia, typically provided by an experienced psychologist. CBT refers to a variety of behavioral strategies used to correct harmful or negative thought patterns and behaviors that can cause or worsen insomnia. This type of therapy is not only effective, but its benefits outlast those of medications. Examples of CBT include relaxation therapy and biofeedback (a type of therapy that uses medical monitoring equipment to help patients learn to relax by controlling their vital signs — heart rate, breathing, etc).

 

People with insomnia should also adopt healthy habits and rituals that promote a good night’s sleep. These include:

 

Thinking positively

Establishing fixed bed and wake times

Relaxing before going to bed

Maintaining a comfortable sleeping environment

Avoiding clock watching

Following a 20 minute “Toss and Turn” rule (giving yourself only 20 minutes to continue tossing and turning, before leaving the bed for some restful activity)

Using the bedroom for sleep and sex only

Avoiding daytime naps

Avoiding caffeine, alcohol, and nicotine within 6 hours of sleep

Exercising regularly but not within 3 hours of sleep

 

All health professionals should be asking about your sleep habits when they are talking to you.  Irregular sleep patterns, mind racing with thoughts, heart palpitations, inability to sleep for 5 hours straight, are all signs of underlying diseases and some serious conditions.  Many times this can be fixed with the right vitamin and supplement program.  We have found many people who are taking supplements but we the wrong amount or the wrong combination for them.

 

If you would like to make an appointment with us please just call, leave a voice message if no one can pick up at that time, and we will be happy to help you.

 

Health and Wellness Associates

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P Carrotners

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Health and Disease, Uncategorized

A Tiny Does of This Can Protect Against Cancer, MS, and Depression

melatonin

A Tiny Dose of This Can Help Protect Against Cancer, MS, and Depression

 

How Melatonin May Benefit Depression, Autoimmune Disorders, and Cancer

 

The hormone melatonin plays many important roles in your health, from helping you sleep better to strengthening your immune system, slowing down brain aging, reducing migraine attacks, protecting bone mass, and preventing cancer.

 

Lack of sun exposure during the day combined with artificial lighting late into the night disrupts your biological clock and hence, your melatonin production, and this disruption can provoke a number of adverse health effects.

 

In fact, melatonin has been the subject of preclinical research on over 100 different disease applications, many of which go hand in hand with your need for sleep.

 

Melatonin for Sleep and Beyond

 

Your master biological clock resides in the suprachiasmatic nucleus of your brain (SCN), which is part of your hypothalamus. Based on signals of light and darkness, your SCN tells your pineal gland when it’s time to secrete melatonin, and when to turn it off.

 

In scientific studies, melatonin supplementation has been shown to help people fall asleep faster and stay asleep, experience less restlessness, and prevent daytime fatigue.

 

Keep in mind that you may only need a very minimal dose. I recommend taking only 0.25 mg or 0.5 mg to start, and adjusting upward from there. Taking higher doses, such as 3 mg, can sometimes make you more wakeful instead of sleepier, so start low and adjust your dose as needed.

 

Melatonin has also been found to reduce the effects of jet lag when traveling across multiple time zones.1 And children suffering with eczema, a condition that oftentimes prevents good sleep, may also get more shut-eye with melatonin supplementation,2 according to recent research.

 

Interestingly, melatonin also helped dampen the severity of the eczema, hinting at its anti-inflammatory effects. However, the benefits of melatonin go far beyond sleep. Three specific areas I’ll address in this article are its role in depression, multiple sclerosis, and cancer.

 

Normalizing Your Circadian System Helps Alleviate Depressive Symptoms

 

Your melatonin level inversely rises and falls with light and darkness, and both your physical and mental health is intricately tied to this rhythm of light and dark. When it’s dark, your melatonin levels increase, which is why you may feel tired when the sun starts to set.

 

Conversely, when you’re exposed to bright artificial lighting at night, including blue light emitted from TVs and electronic screens, you may have trouble falling asleep due to suppressed melatonin levels.

 

Light exposure when you wake up at night can also be problematic as I explain in my video above. However you don’t have to stumble around as red and orange wavelengths will not suppress melatonin production.

 

You can use a red light to guide you to the bathroom. If you have a clock in your bedroom make sure it has a red LED display. Blue would be the worst as it is the one that shuts down melatonin most effectively.

 

Winter Blues SAD

 

Seasonal affective disorder (SAD, also called “the winter blues”) is associated with lack of sun exposure, and scientists generally recommend full-spectrum light therapy over SSRIs like Prozac or Zoloft for this condition.

 

Interestingly, recent research suggests light therapy may be preferable even for major depression, outperforming Prozac in those with moderate to severe depression. One of the reasons it works so well likely has to do with the fact that bright light helps reset your biological clock, or circadian rhythm.

 

Melatonin supplementation can help do this to a certain extent as well, but not as effectively as exposure to bright light during daytime. Light may also work in a way similar to antidepressants by regulating neurotransmitter function.

 

Light Therapy — More Effective Than Prozac

 

The study3,4,5,6,7 in question set out to compare the effectiveness of light therapy alone and in conjunction with the antidepressant fluoxetine (Prozac).

 

The eight-week long trial included 122 adults between the ages of 19 and 60, who were diagnosed with moderate to severe depression. The participants were divided into four groups, receiving:

 

Light therapy (30 minutes per day upon waking using a 10,000 lux Carex brand day-light device, classic model) plus a placebo pill

Prozac (20 mg/day) plus a deactivated ion generator serving as a placebo light device

Light therapy plus Prozac

Placebo light device plus placebo pill (control group)

In conclusion, the study found that the combination of light therapy and Prozac was the most effective — but light therapy-only came in close second, followed by placebo.

 

That’s right, the drug treatment was the least effective of all, and LESS effective than placebo! At the end of the study, remission was achieved by:

 

Just over 19 percent in the Prozac only group

30 percent in the placebo group

Nearly 44 percent in the light therapy only group

Nearly 59 percent in the active combination group

How Melatonin May Aid in the Treatment of Multiple Sclerosis

 

Multiple sclerosis (MS) is an autoimmune disorder that, like SAD, has been linked to vitamin D deficiency from lack of sun exposure. Interestingly, recent research suggests that a drop in autumn and winter relapses may be linked to peak melatonin levels, which occurs during these darker months.

 

Conversely, spikes in relapses occurring during spring and summer — which tend to be less common but do occur — may be related to decreased melatonin levels. The research,8 led by neuroscientist Mauricio Farez at the Dr. Raúl Carrea Institute for Neurological Research, looked at 139 MS patients living in Buenos Aires.

 

Thirty-two percent of them experienced a reduction in relapses during fall and winter, compared to spring and summer. As reported by Scientific American:9

 

“Past research has shown that melatonin can have a protective effect against MS and that shift work, which disturbs melatonin production, can increase the risk of developing the disease. According to the authors, this research is one of the first to bring together epidemiological evidence with results from both human cells and animal models …

 

[And it] may help to resolve a ‘seasonal paradox’ — MS flare-ups should decrease during warmer, brighter months when people receive more exposure to sunlight and thus produce more vitamin D, which also has anti-inflammatory properties. But some studies, including this one, show that relapses increase in the spring and summer pointing to the possibility that other environmental factors, such as melatonin levels, are involved.”

 

To test their hypothesis, mice with autoimmune encephalomyelitis (the animal model of MS) received daily injections of melatonin. As a result, clinical symptoms were reduced, and harmful T cells, which are pro-inflammatory, were reduced, whereas regulatory T cells were increased. Similar effects were shown in petri dish experiments. As noted in the featured article:

 

“Melatonin regulates pathways central to the immune response, so these results may pertain to other autoimmune diseases, particularly where seasonal flare-ups occur, such as lupus and rheumatoid arthritis …”

 

Melatonin’s Role in Fighting Cancer

 

Cancer is another area where melatonin plays a major role. The evidence suggests it may be an important adjunct to cancer treatment,10 as it also helps protect against the toxic effects of radiation therapy. Cells throughout your body — even cancer cells — have melatonin receptors, and melatonin is in and of itself cytotoxic, meaning can induce tumor cell death (apoptosis). It also:11

 

Boosts production of immune-optimizing substances such as interleukin-2, which helps identify and attack mutated cells that lead to malignant cancer

Inhibits development of new tumor blood vessels (tumor angiogenesis), which slows the spread of the cancer

Retards cancer progression by activating the cytokine system, which helps inhibit tumor growth, and by stimulating the cytotoxic activity of macrophages and monocytes

By its antioxidant action it also limits oxidative damage to DNA

Inhibits tumor growth by counteracting estrogen. (At night, when melatonin production peaks, cell division slows. And when melatonin latches onto a breast cancer cell, it has been found to counteract estrogen’s tendency to stimulate cell growth)

Melatonin has a calming effect on other reproductive hormones besides estrogen as well, which may explain why it seems to protect most effectively against sex hormone-driven cancers, including ovarian, endometrial, prostate, testicular and breast cancers12 — the latter of which has received the greatest amount of scientific attention. Some of the studies on melatonin for breast cancer include the following:

 

The journal Epidemiology13 reported increased breast cancer risk among women who work predominantly night shifts

Women who live in neighborhoods with large amounts of nighttime illumination are more likely to get breast cancer than those who live in areas where nocturnal darkness prevails, according to an Israeli study14

From participants in the Nurses’ Health Study,15 it was found that nurses who work nights had 36 percent higher rates of breast cancer

Blind women, whose eyes cannot detect light and therefore have robust production of melatonin, have lower-than-average breast cancer rates16

When the body of epidemiological studies are considered in their totality, women who work night shift are found to have breast cancer rates 60 percent above normal, even when other factors, such as differences in diet, are accounted for17

Melatonin May Improve Outcomes for Lung Cancer Patients

 

Other cancers may also benefit. In 2004, the Life Extension Foundation collaborated with Cancer Treatment Centers of America on the first clinical trial evaluating melatonin’s effect in patients with lung cancer.

 

The results,18 which were published in conjunction with the 2014 American Society of Clinical Oncology Meeting, found a tumor response in just over 29 percent of those receiving melatonin at night, compared to just under 8 percent of those receiving it in the morning, and 10.5 percent of placebo recipients. As reported by Life Extension Magazine:19

 

“European clinical studies indicate that in patients with metastatic non-small-cell lung cancer, five-year survival and overall tumor regression rates were higher in patients concomitantly treated with melatonin than in those treated with chemotherapy alone. While no patient treated with chemotherapy survived after two years, five-year survival was achieved in 3 of 49 patients treated with chemotherapy and melatonin.

 

The researchers hope that similarly promising results could eventually convince mainstream medical practitioners to administer melatonin in combination with standard cancer treatment regimens to patients in earlier stages of cancer treatment.”

 

The Importance of Light and Dark for the Synchronization of Your Body Clocks

 

Melatonin production is stimulated by darkness and suppressed by light, which is why your levels should be highest just prior to bedtime. This perfectly orchestrated system allows you to fall asleep when the sun sets and awaken refreshed with the sunrise, while also providing potential anti-aging and disease-fighting benefits.

 

If you’re having trouble sleeping, which is a signal that your melatonin production is off, I suggest making sure you’re sleeping in total darkness and to turn lights down at least an hour or so before bedtime. Also, avoid watching TV and using computers and other electronic gadgets at least an hour prior to bed.

 

All of these devices emit blue light, which will decrease your melatonin if you work past dark, so ideally you’d want to turn these items off once the sun goes down. If you have to use these devices you can wear yellow glasses that filter the blue wavelengths out and/or use free software like f.lux.

 

To light rooms at night, use “low blue” light bulbs that emit an amber light instead of the blue that suppresses melatonin production. An equally important factor is the quality of light you’re exposed to during the day. Without sufficient sunlight during the day, your circadian clock may fall out of sync.

 

Most incandescent and fluorescent lights emit very poor-quality light. What your body needs for optimal functioning is the full-spectrum light you get outdoors, but most of us do not spend much time outside to take advantage of this healthy light.

 

Using full-spectrum light bulbs in your home and office can help ameliorate this lack of high-quality sunlight during the day, but cannot fully replace it. So do make an effort to go outside for at least 30 to 60 minutes each day during the brightest portion of the day, i.e. right around noon. This will help “set” your circadian clock and help you sleep better.

 

For Optimal Health, Make Sure You Sleep Well

 

Remember, when your circadian rhythms are disrupted, your body produces less melatonin, which means it has less ability to fight cancer, and less protection against free radicals that may accelerate aging and disease. So if you’re having even slight trouble sleeping, I suggest you review my “33 Secrets to a Good Night’s Sleep” for more guidance on how to improve your sleep-wake cycle.

 

If you’ve made the necessary changes to your sleep routine and find you’re still having trouble sleeping, a high-quality melatonin supplement may be helpful.

 

The amount of melatonin you create and release every night varies depending on your age. Children usually have much higher levels of melatonin than adults, and as you grow older your levels typically continue to decrease. This is why some older adults may benefit from extra melatonin.

 

The same goes for those who perform night shift work, travel often and experience jet lag, or otherwise suffer from occasional sleeplessness due to stress or other reasons. Start with a dose of about 0.25 to 0.5 mg, and increase it as necessary from there. If you start feeling more alert, you’ve likely taken too much and need to lower your dose.

 

Health and Wellness Associates

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312-972-WELL